Considerations for and Mechanisms of Adjunct Therapy in COPD

Inhaled bronchodilators and corticosteroids, when indicated, form the backbone of COPD therapy. However, over last decade there has been an emergence adjunct therapies in oral or inhaled that are now part therapeutic approach to COPD. While these have shown be beneficial used appropriate instances, particular considerations need minded using therapies. This review article discussed mechanism roflumilast, macrolide antibiotics, other chronic antibiotic regimens, vitamin D supplementation, n-acetylcysteine, nebulized hypertonic saline, clinical data behind each therapies, adverse events associated with therapy, expert recommendations for their utilization. Our goal is provide a brief but informative clinically useful commonly encountered advanced